Date of Publication: 10-Sep-25
Antibodies, also known as immunoglobulins, are Y-shaped glycoproteins that are produced by the immune system in response to foreign molecules (antigens) that enter the body. The term antigen refers to any substance that is capable of inducing an immune response, encompassing a diverse range of entities, including viruses, fungi, bacteria, proteins on the surface of cells, and non-living substances, such as toxins, chemicals and foreign particles.
The global antibody discovery market, valued at $2.0 billion in 2024, is projected to reach $2.4 billion in 2025 and $6.6 billion by 2035, representing a CAGR of 10.5% during the forecast period.
Once developed, these antibodies can protect an individual from getting re-infected by a certain pathogen. These biomolecules are produced by B-lymphocytes and circulate within the bloodstream and lymphatic system, where they bind to a specific antigen and facilitate its clearance from circulation via diverse effector mechanisms. The antibody works by recognizing and binding to a specific region on an antigen, called an epitope, and mediates an immune response against it. Upon binding to the epitope, it facilitates phagocytosis of the foreign substances by a process termed as opsonization. As the antibodies can be produced to target specific proteins, they are considered as highly important biomolecules that have the potential to be used in the treatment of various diseases. Further, the antibodies also work in activating the complement system to destroy the bacterial cell by lysis Therefore, owing to the vast potential of antibodies, the healthcare industry has witnessed a substantial increase in demand for antibody therapeutics in the recent past.
Over time, biologics have established a strong foothold in the healthcare industry. Since many of these products are personalized treatment options, they are highly specific and characterized by favourable safety profiles. Antibody based pharmacological interventions represent the largest and fastest growing biologic product class. It is worth mentioning that antibodies also form the basis of certain cell therapies and are used for diagnostic purposes.
Given the growing demand for antibodies across therapeutics, diagnostics and research use, the role of contract service providers offering biologic development and manufacturing expertise has become indispensable. Moreover, in recent years, the establishment of several contract research organizations (CROs) and contract manufacturing organizations (CMOs) specializing in antibody discovery / development has been observed. These companies / organizations have elaborate service portfolios, ranging from antigen design and characterization services to development and selection of viable pharmacological leads. Outsourcing is considered as a favorable approach in this field, allowing innovator companies to focus on initial R&D and marketing, while the more seasoned experts at CROs / CMOs handle product development and production responsibilities. This has emerged as a preferred business model among virtual biopharma companies and the smaller players.
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